A 33-year-old man in Baltimore, Maryland, USA, with untreated HIV infection had a 74-day course of mpox with multiorgan system involvement and unique clinical findings. In this clinical experience combining 3 novel therapeutic regimens, this patient died from severe mpox in the context of untreated HIV and advanced immunodeficiency.
Keywords: Baltimore; HIV/AIDS and other retroviruses; Maryland; United States; disease outbreaks; monkeypox virus; mpox; sexually transmitted infections; viruses.