Emerging role of ferroptosis-related circular RNA in tumor metastasis

Yifei Meng; Jingdong Cao; Yidan Li; Saili Duan; Zongjiang Zhou; Jinghe Li; Diabate Ousmane; Chunlin Ou; Junpu Wang

doi:10.3389/fphar.2023.1168458

Emerging role of ferroptosis-related circular RNA in tumor metastasis

Front Pharmacol. 2023 Apr 24:14:1168458. doi: 10.3389/fphar.2023.1168458. eCollection 2023.

Authors

Yifei Meng^{1

2

3

4

5}, Jingdong Cao^{1

2

3

4

5}, Yidan Li^{1

2

3

4

5}, Saili Duan^{1

2

3

4

5}, Zongjiang Zhou^{1

2}, Jinghe Li^{1

2}, Diabate Ousmane^{1

2}, Chunlin Ou^{1

5}, Junpu Wang^{1

2

3

4

5}

Affiliations

¹ Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.
² Department of Pathology, School of Basic Medicine, Central South University, Changsha, China.
³ Department of Pathology, Ultrapathology (Biomedical Electron Microscopy) Center, Xiangya Hospital, Central South University, Changsha City, China.
⁴ Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha, China.
⁵ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

Abstract

Tumor metastasis is an important factor that contributes to the poor prognosis of patients with tumors. Therefore, to solve this problem, research on the mechanism of metastasis is essential. Ferroptosis, a new mode of cell death, is characterized by membrane damage due to lipid peroxidation caused by iron overload. Many studies have shown that excessive ferroptosis can affect tumor metastasis and thus inhibit tumor progression. Recently, circular RNA (circRNA), a type of non-coding RNA, has been shown to be associated with the progression of ferroptosis, thus influencing tumor development. However, the specific mechanisms by which circRNAs affect the progression of ferroptosis and their roles in tumor metastasis are not known. In this review, we systematically discuss the role of circRNAs in regulating tumor ferroptosis and their mechanism of action through sponging miRNAS in various tumors, thereby impacting metastasis. This review helps elucidate the relationship and role of ferroptosis-related circRNAs in tumor metastasis and may provide future researchers with new ideas and directions for targeted therapies.

Keywords: CircRNAs; biomarkers; ferroptosis; therapeutic target; tumor metastasis.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (No. 81903032 and 81602167), the China Postdoctoral Science Foundation (No. 2020M672520), the Outstanding Youth Foundation of Hunan Provincial Natural Science Foundation of China (No. 2022JJ20098), the Hunan Provincial Natural Science Foundation of China (No. 2021JJ31100 and 2021JJ41013), the Central South University Innovation-Driven Research Programme (2023CXQD076) and the Science and Technology Program Foundation of Changsha City (No. kq2004085).