Primary retroperitoneal tumors are rare. Of these, primary retroperitoneal serous carcinoma is extremely rare, with only 15 cases having been reported. A 62-year-old woman presented with abdominal bloating. PET/CT demonstrated 2 tumors showing increased FDG uptake lateral and medial to the right common iliac vessels, without other abnormal uptake. A laparotomy revealed no ascites or abnormalities except a myomatous uterus in the peritoneal cavity. After surgical removal of these retroperitoneal tumors, the patient received adjuvant paclitaxel/carboplatin chemotherapy and remained well for 80 months. This case points to the significance of 18 F-FDG PET/CT in determining the nature of retroperitoneal tumors.
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