68 Ga-FAPI PET/CT Imaging of the Pancreas in a Patient With Fulminant Type 1 Diabetes

Clin Nucl Med. 2023 Jul 1;48(7):620-621. doi: 10.1097/RLU.0000000000004684. Epub 2023 May 11.

Abstract

Fulminant type 1 diabetes is a recently recognized diabetes subtype characterized by extremely rapid destruction of the pancreatic beta cells, leading to an absolute deficiency in insulin secretion. Fulminant type 1 diabetes is clinically characterized by the drastic onset of hyperglycemia and ketoacidosis within a few days, as well as near-normal glycated hemoglobin (HbA 1c ) levels despite remarkable hyperglycemia at initial presentation. A 41-year-old woman diagnosed with fulminant type 1 diabetes underwent 68 Ga-FAPI PET/CT, which showed intense FAPI uptake throughout the pancreas, especially in the pancreatic tail. Contrast-enhanced abdominal CT failed to reveal any pancreatic abnormalities. This case indicated that 68 Ga-FAPI PET/CT might be useful for evaluating patients with fulminant type 1 diabetes.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Diabetes Mellitus, Type 1* / complications
  • Diabetes Mellitus, Type 1* / diagnostic imaging
  • Female
  • Fluorodeoxyglucose F18
  • Gallium Radioisotopes
  • Humans
  • Hyperglycemia*
  • Pancreas / diagnostic imaging
  • Positron Emission Tomography Computed Tomography

Substances

  • Gallium-68
  • Gallium Radioisotopes
  • Fluorodeoxyglucose F18