Azide-Enolate Cycloaddition-Rearrangement Enables Direct α-Amination of Amides and Enelactam Synthesis from Esters

Joseph J Bell-Tyrer; Paul A Hume; Phillip S Grant; Margaret A Brimble; Daniel P Furkert

doi:10.1002/chem.202301235

Azide-Enolate Cycloaddition-Rearrangement Enables Direct α-Amination of Amides and Enelactam Synthesis from Esters

Chemistry. 2023 Jun 2;29(31):e202301235. doi: 10.1002/chem.202301235. Epub 2023 May 11.

Authors

Joseph J Bell-Tyrer¹, Paul A Hume², Phillip S Grant¹, Margaret A Brimble¹, Daniel P Furkert¹

Affiliations

¹ School of Chemical Sciences and, Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, 23 Symonds St, Auckland, 1010, New Zealand.
² School of Chemical & Physical Sciences, Victoria University of Wellington, Kelburn Parade, Wellington, 6012, New Zealand.

PMID: 37166050
DOI: 10.1002/chem.202301235

Abstract

Invited for the cover of this issue are Dan Furkert, Joe Bell-Tyrer and co-workers at the University of Auckland and Victoria University of Wellington. The image depicts a tandem cycloaddition-rearrangement process delivering a diverse range of molecular frameworks from simple precursors. Read the full text of the article at 10.1002/chem.202300261.