GADD45B predicts lung squamous cell carcinoma survival and impacts immune infiltration, and T cell exhaustion

Ying Lv; Zeyu Liu; Kai Xiong; Hailing Duan; Jiuyu Yang; Pan Liao

doi:10.1080/08916934.2023.2209706

GADD45B predicts lung squamous cell carcinoma survival and impacts immune infiltration, and T cell exhaustion

Autoimmunity. 2023 Dec;56(1):2209706. doi: 10.1080/08916934.2023.2209706.

Authors

Ying Lv¹, Zeyu Liu², Kai Xiong³, Hailing Duan⁴, Jiuyu Yang¹, Pan Liao⁵

Affiliations

¹ Department of Cardiology, Inner Mongolia Forestry General Hospital, (The Second Clinical Medical School of Inner Mongolia, University for the Nationalities), Yakeshi, Inner Mongolia, China.
² Department of Cardiothoracic surgery, Inner Mongolia Forestry General Hospital, (The Second Clinical Medical School of Inner Mongolia, University for the Nationalities), Yakeshi, Inner Mongolia, China.
³ Department of Statistics, Inner Mongolia Forestry General Hospital, (The Second Clinical Medical School of Inner Mongolia, University for the Nationalities), Yakeshi, Inner Mongolia, China.
⁴ Department of Oncology, Inner Mongolia Forestry General Hospital, (The Second Clinical Medical School of Inner Mongolia, University for the Nationalities), Yakeshi, Inner Mongolia, China.
⁵ The School of Medicine, Nankai University, Tianjin, China.

PMID: 37165780
DOI: 10.1080/08916934.2023.2209706

Abstract

Background: This study focussed on exploring the prognostic prediction performance of the growth arrest and DNA damage-inducible 45 beta (GADD45B) and its associations with T-cell activity and immune soakage in different malignancies, especially lung squamous cell carcinoma (LUSC).

Methods: We applied TIMER database for comparing the expressions of GADD45B among different cancers. OncoLnc, Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and Kaplan-Meier Plotter were utilised to evaluate the prognostic prediction performance of GADD45B. Besides, the associations of GADD45B with clinical stage, associated gene markers, and immune infiltration were examined through TISIDB, GEPIA2, and Tumour Immune Estimation Resource (TIMER). Biological processes (BPs) and KEGG enrichment analyses were performed to illustrate the possible role of GADD45B in LUSC. The miRWalk database was adopted to analyse the gene miRNA interaction network of GADD45B in LUSC.

Results: GADD45B expression was decreased in most of the malignancies, with relation to the poor prognosis in LUSC. GADD45B also significantly affected the survival of LUSC subgroups divided by clinic data. GADD45B significantly correlates with and may stimulate T cell exhaustion in LUSC.

Conclusions: GADD45B is a prognostic indicator in multiple tumours, especially in LUSC. Moreover, modulating GADD45B expression may improve immunotherapy efficacy in LUSC.

Keywords: GADD45B; Immune infiltration; Lung squamous cell carcinoma; T cells exhaustion; prognosis.

MeSH terms

Antigens, Differentiation / genetics
Carcinoma, Non-Small-Cell Lung*
Carcinoma, Squamous Cell* / diagnosis
Carcinoma, Squamous Cell* / genetics
Gene Expression Regulation, Neoplastic
Humans
Lung
Lung Neoplasms* / genetics
Prognosis
T-Cell Exhaustion

Substances

GADD45B protein, human
Antigens, Differentiation