NAD+ metabolism-based immunoregulation and therapeutic potential

Jiankai Fang; Wangwang Chen; Pengbo Hou; Zhanhong Liu; Muqiu Zuo; Shisong Liu; Chao Feng; Yuyi Han; Peishan Li; Yufang Shi; Changshun Shao

doi:10.1186/s13578-023-01031-5

NAD⁺ metabolism-based immunoregulation and therapeutic potential

Cell Biosci. 2023 May 10;13(1):81. doi: 10.1186/s13578-023-01031-5.

Authors

Jiankai Fang^#¹, Wangwang Chen^#², Pengbo Hou^{1

3}, Zhanhong Liu^{1

3}, Muqiu Zuo¹, Shisong Liu¹, Chao Feng^{1

3}, Yuyi Han^{1

3}, Peishan Li⁴, Yufang Shi^{5

6}, Changshun Shao⁷

Affiliations

¹ Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, The First Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
² Laboratory Animal Center, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
³ Department of Experimental Medicine and Biochemical Sciences, TOR, University of Rome Tor Vergata, Rome, Italy.
⁴ Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, The First Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China. psli@suda.edu.cn.
⁵ Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, The First Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China. yfshi@suda.edu.cn.
⁶ Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. yfshi@suda.edu.cn.
⁷ Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, The First Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China. shaoc@suda.edu.cn.

^# Contributed equally.

Abstract

Nicotinamide adenine dinucleotide (NAD⁺) is a critical metabolite that acts as a cofactor in energy metabolism, and serves as a cosubstrate for non-redox NAD⁺-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases. NAD⁺ metabolism can regulate functionality attributes of innate and adaptive immune cells and contribute to inflammatory responses. Thus, the manipulation of NAD⁺ bioavailability can reshape the courses of immunological diseases. Here, we review the basics of NAD⁺ biochemistry and its roles in the immune response, and discuss current challenges and the future translational potential of NAD⁺ research in the development of therapeutics for inflammatory diseases, such as COVID-19.

Keywords: Disease therapy; Immunoregulation; Metabolic homeostasis; Nicotinamide adenine dinucleotide (NAD+); Plasticity.

Publication types

Review

Abstract

Publication types

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