When SLC46A2 delivers cargo into keratinocytes

Xinxin Wang; Yuping Lai

doi:10.1016/j.immuni.2023.04.008

When SLC46A2 delivers cargo into keratinocytes

Immunity. 2023 May 9;56(5):897-900. doi: 10.1016/j.immuni.2023.04.008.

Authors

Xinxin Wang¹, Yuping Lai²

Affiliations

¹ Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, P.R. China.
² Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, P.R. China; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, School of Life Sciences, East China Normal University, Shanghai, P.R. China. Electronic address: yplai@bio.ecnu.edu.cn.

PMID: 37163988
DOI: 10.1016/j.immuni.2023.04.008

Abstract

How pattern recognition receptors NOD1 and NOD2 sense bacterial muropeptides from extracellular bacteria to drive keratinocyte inflammation remains unclear. In this issue of Immunity, Bharadwaj et al. show that the solute carrier 46A2 (SLC46A2) delivers DAP-muropeptides into the cytosol to drive NOD1 activation in keratinocytes and elicit skin inflammation during psoriasis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Inflammation*
Nod1 Signaling Adaptor Protein / metabolism
Nod2 Signaling Adaptor Protein / metabolism
Receptors, Pattern Recognition*

Substances

Nod1 Signaling Adaptor Protein
Nod2 Signaling Adaptor Protein
Receptors, Pattern Recognition
SLC46A2 protein, human