4,6-Diamino-2-thiopyrimidine-based Cobalt Metal Organic Framework (Co-DAT-MOF): green, efficient, novel and reusable nanocatalyst for synthesis of multicomponent reactions

Arash Ghorbani-Choghamarani; Zahra Kakakhani; Zahra Taherinia

doi:10.1038/s41598-023-34001-5

4,6-Diamino-2-thiopyrimidine-based Cobalt Metal Organic Framework (Co-DAT-MOF): green, efficient, novel and reusable nanocatalyst for synthesis of multicomponent reactions

Sci Rep. 2023 May 9;13(1):7502. doi: 10.1038/s41598-023-34001-5.

Authors

Arash Ghorbani-Choghamarani¹, Zahra Kakakhani², Zahra Taherinia²

Affiliations

¹ Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, Iran. a.ghorbani@basu.ac.ir.
² Department of Chemistry, Faculty of Science, Ilam University, Ilam, Iran.

Abstract

In this study, Co-DAT-MOF powder was prepared via the solvothermal method using 4, 6-diamino-2-thiopyrimidine as the organic linker and Co(NO₃)₂·6H₂O. The synthesized catalysts are characterized using XRD, FT-IR, TGA, SEM, BET, NH₃-TPD, and ICP-OES techniques. SEM analysis clearly indicated the formation of nanosheet microspheres. NH₃-TPD-MS was employed as a means of identifying the various strengths of acid sites and their relative abundance in an attempt to explain the effect of the catalyst surface acid sites. We identified a new acidic feature in Co-DAT-MOF catalyst, related to the presence of desorption peaks in the NH₃-TPD profiles. The activity of Co-DAT-MOF catalyst for the synthesis of multicomponent reactions correlates with lewis acidity. In addition, Co-DAT-MOF exhibited excellent performance for the synthesis of pyrroloacridine-1(2H)-one and chromeno [2, 3- d] pyrimidin-8-amines, as well as good reusability and recyclability.