By using colliding-pulse mode-locking (CPM) configuration with asymmetric cladding layer and coating, 1.5-µm AlGaInAs/InP multiple quantum well (MQW) CPM lasers with high-power and ultra-short pulse generation capability at a repetition rate of 100 GHz are reported. The laser adopts a high-power epitaxial design, with four pairs of MQWs and an asymmetrical dilute waveguide cladding layer to reduce the internal loss, maintaining good thermal conductivity while increasing the saturation energy of the gain region. The asymmetric coating is introduced, as compared to conventional CPM laser with symmetric reflectivity, to further increase the output power and shorten the pulse width. With a high reflection (HR) coating of 95% on one facet and another facet as cleaved, 100-GHz sub-picosecond optical pulses with peak power on a Watt level are demonstrated. Two mode-locking states, the pure CPM state and the partial CPM state, are investigated. Pedestal-free optical pulses are obtained for both states. For the pure CPM state, a pulse width of 564 fs, an average power of 59 mW, a peak power of 1.02 W, and an intermediate mode suppression ratio over 40 dB are demonstrated. For the partial CPM state, a pulse width of 298 fs is demonstrated.