Single probes and resonant four-wave-mixing enabling novel correlative light electron microscopy workflow

Long Chen; Chao He

doi:10.1038/s41377-023-01154-x

Single probes and resonant four-wave-mixing enabling novel correlative light electron microscopy workflow

Light Sci Appl. 2023 May 8;12(1):111. doi: 10.1038/s41377-023-01154-x.

Authors

Long Chen¹, Chao He²

Affiliations

¹ Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK. long.chen@strubi.ox.ac.uk.
² Department of Engineering Science, University of Oxford, Oxford, OX1 3PJ, UK. chao.he@eng.ox.ac.uk.

Abstract

Correlative light electron microscopy prefers single probes with stable performance in both optical and electron microscopy. Now researchers have shown how to harness gold nanoparticles featuring exceptional photostability and four-wave-mixing nonlinearity to realize a new correlation imaging approach.