Estradiol and leptin: no engagement without CITED1

Olga Barca-Mayo; Miguel López

doi:10.1016/j.tem.2023.04.002

Estradiol and leptin: no engagement without CITED1

Trends Endocrinol Metab. 2023 Jul;34(7):389-391. doi: 10.1016/j.tem.2023.04.002. Epub 2023 May 7.

Authors

Olga Barca-Mayo¹, Miguel López²

Affiliations

¹ Circadian and Glial Biology Group, Department of Physiology, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), University of Santiago de Compostela, 15782 Santiago de Compostela, Spain. Electronic address: olga.barca.mayo@usc.es.
² NeurObesity Group, Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red (CIBER) Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 15706 Santiago de Compostela, Spain. Electronic address: m.lopez@usc.es.

PMID: 37156656
DOI: 10.1016/j.tem.2023.04.002

Abstract

Ovarian estradiol and leptin are important modulators of whole-body energy homeostasis that act in the hypothalamus. In a recent paper in Cell Metabolism, González-García et al. demonstrate that CITED1 acts as a key hypothalamic cofactor that mediates the antiobesity effects of estradiol through potentiation of the anorectic actions of leptin.

Keywords: CITED1; arcuate nucleus of the hypothalamus; estradiol; feeding; leptin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Obesity Agents* / pharmacology
Arcuate Nucleus of Hypothalamus / metabolism
Estradiol* / pharmacology
Humans
Hypothalamus / metabolism
Leptin* / pharmacology

Substances

Estradiol
Leptin
CITED1 protein, human
Anti-Obesity Agents