Emerging treatments for itch in atopic dermatitis: A review

Angelina Labib; Teresa Ju; Gil Yosipovitch

doi:10.1016/j.jaad.2023.04.057

Emerging treatments for itch in atopic dermatitis: A review

J Am Acad Dermatol. 2023 Aug;89(2):338-344. doi: 10.1016/j.jaad.2023.04.057. Epub 2023 May 6.

Authors

Angelina Labib¹, Teresa Ju¹, Gil Yosipovitch²

Affiliations

¹ Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, Florida.
² Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, Florida. Electronic address: gyosipovitch@med.miami.edu.

PMID: 37156337
DOI: 10.1016/j.jaad.2023.04.057

Abstract

Atopic dermatitis is a chronic inflammatory skin condition with a high prevalence that is increasing. The most universal symptom in patients with atopic dermatitis is pruritus; it is often the most troublesome symptom. New insights on the mechanism of itch in patients with eczema have been elucidated, involving cross-talk between neural and immune systems, which have advanced our treatments significantly. In the last few years, there are emerging treatments currently undergoing investigation that yield a promising outlook in treating this symptom. In this review, we aimed to provide an updated overview of future treatments undergoing phase II and III clinical trials that may be used to treat pruritus of atopic dermatitis.

Keywords: atopic dermatitis; biologics; eczema; immunomodulators; itch; monoclonal antibodies; pruritus; small molecule therapies.

Publication types

Review

MeSH terms

Dermatitis, Atopic* / complications
Dermatitis, Atopic* / drug therapy
Humans
Pruritus / drug therapy
Pruritus / etiology