Thio(seleno)cyano-difluoroalkylation of Alkenes Using Visible-Light Photocatalysis

Ye Rin Choi; Seok Beom Lee; Jae Kyun Lee; Yoonna Kwak; Hongchan An; Sungwook Choi; Ki Bum Hong

doi:10.1021/acs.orglett.3c01206

Thio(seleno)cyano-difluoroalkylation of Alkenes Using Visible-Light Photocatalysis

Org Lett. 2023 May 19;25(19):3564-3567. doi: 10.1021/acs.orglett.3c01206. Epub 2023 May 8.

Authors

Ye Rin Choi¹, Seok Beom Lee², Jae Kyun Lee³, Yoonna Kwak¹, Hongchan An¹, Sungwook Choi², Ki Bum Hong¹

Affiliations

¹ New Drug Development Center (NDDC), Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), 80 Cheombok-ro, Dong-gu, Daegu 41061, Republic of Korea.
² Department of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea.
³ Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.

PMID: 37155717
DOI: 10.1021/acs.orglett.3c01206

Abstract

A mild and efficient three-component thio(seleno)cyano-difluoroalkylation of simple alkenes is demonstrated using an iridium(ruthenium) photocatalyst. This protocol provides a direct and regioselective installation of both C-S(Se)CN [thio(seleno)cyanation] and C-C_F (difluoroalkylation) bonds.