Intrinsic sexual dimorphism in the placenta determines the differential response to benzene exposure

Anthony Maxwell; Nicholas Adzibolosu; Anna Hu; Yuan You; Paul M Stemmer; Douglas M Ruden; Michael C Petriello; Marianna Sadagurski; Lucas K Debarba; Lisa Koshko; Jayanth Ramadoss; Annie Thy Nguyen; Darby Richards; Aihua Liao; Gil Mor; Jiahui Ding

doi:10.1016/j.isci.2023.106287

Intrinsic sexual dimorphism in the placenta determines the differential response to benzene exposure

iScience. 2023 Feb 27;26(4):106287. doi: 10.1016/j.isci.2023.106287. eCollection 2023 Apr 21.

Authors

Affiliations

¹ C.S Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA.
² Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, USA.
³ Institute of Environmental Health Sciences and Department of Pharmacology, Wayne State University, Detroit, MI, USA.
⁴ Department of Biological Sciences, Integrative Biosciences Center, Wayne State University, Detroit, MI, USA.
⁵ School of Medicine, Wayne State University, Detroit, MI, USA.
⁶ Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.

Abstract

Maternal immune activation (MIA) by environmental challenges is linked to severe developmental complications, such as neurocognitive disorders, autism, and even fetal/maternal death. Benzene is a major toxic compound in air pollution that affects the mother as well as the fetus and has been associated with reproductive complications. Our objective was to elucidate whether benzene exposure during gestation triggers MIA and its impact on fetal development. We report that benzene exposure during pregnancy leads MIA associated with increased fetal resorptions, fetal growth, and abnormal placenta development. Furthermore, we demonstrate the existence of a sexual dimorphic response to benzene exposure in male and female placentas. The sexual dimorphic response is a consequence of inherent differences between male and female placenta. These data provide crucial information on the origins or sexual dimorphism and how exposure to environmental factors can have a differential impact on the development of male and female offspring.

Keywords: Developmental biology; Immunology; Omics; Toxicology.

Abstract

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