Surgical strategies of complicated pheochromocytomas/paragangliomas and literature review

Xu Wang; Yang Zhao; Zhangcheng Liao; Yushi Zhang

doi:10.3389/fendo.2023.1129622

Surgical strategies of complicated pheochromocytomas/paragangliomas and literature review

Front Endocrinol (Lausanne). 2023 Apr 21:14:1129622. doi: 10.3389/fendo.2023.1129622. eCollection 2023.

Authors

Xu Wang¹, Yang Zhao¹, Zhangcheng Liao¹, Yushi Zhang¹

Affiliation

¹ Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Abstract

Pheochromocytomas (PCC)/paragangliomas (PGL) are catecholamine (CA) -secreting neuroendocrine tumors, which are known as PPGL due to their histological and pathophysiological similarities. In addition to the typical triad of paroxysmal headache, palpitation, and sweating, PPGL may also be accompanied by symptoms and signs involving multiple organs and systems such as the cardiovascular system, digestive system, endocrine system, and nervous system. Currently, surgical resection is the first choice for PPGL. Safe and effective surgical management of complicated PPGL is the goal of clinical work. In this paper, we discuss this hot issue based on complicated PPGL cases, aiming to share our experience of the surgical management strategy of PPGL.

Keywords: catecholamine; multidisciplinary treatment; paragangliomas; pheochromocytomas; surgery.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adrenal Gland Neoplasms* / diagnosis
Catecholamines
Humans
Neuroendocrine Tumors*
Paraganglioma* / pathology
Pheochromocytoma* / pathology

Substances

Catecholamines

Grants and funding

This study was funded by the National High Level Hospital Clinical Research Funding (2022-PUMCH-B-010).