PREDICTORS OF MULTIFOCAL PAPILLARY THYROID CANCER. DO THEY EXIST?

O V Mazur; V A Palamarchuk; O A Tovkai; V V Kuts; V O Shidlovskyi; M I Sheremet; R D Levchuk; I I Morozovych; O V Lazaruk; D Cretoiu

doi:10.4183/aeb.2022.424

PREDICTORS OF MULTIFOCAL PAPILLARY THYROID CANCER. DO THEY EXIST?

Acta Endocrinol (Buchar). 2022 Oct-Dec;18(4):424-428. doi: 10.4183/aeb.2022.424.

Authors

O V Mazur¹, V A Palamarchuk¹, O A Tovkai¹, V V Kuts^{1

2}, V O Shidlovskyi³, M I Sheremet⁴, R D Levchuk⁵, I I Morozovych⁵, O V Lazaruk⁶, D Cretoiu⁷

Affiliations

¹ Ukrainian Scientific and Practical Center of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine.
² State institution National Institute of Tuberculosis and Pulmonology, "F.G. Yanovsky" National Academy of Medical Sciences of Ukraine.
³ "I. Horbachevsky" Ternopil National Medical University, Ministry of Education of Ukraine, Ternopil.
⁴ Bukovinian State Medical University, Department of Surgery №1, Ministry of Education of Ukraine, Chernivtsi.
⁵ Communal non-profit enterprise Ternopil Municipal City Hospital №2.
⁶ Bukovinian State Medical University, Department of Pathology, Chernivtsi, Ukraine.
⁷ "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Abstract

The aim of this study is to analyze and identify the main predictors that may indicate multifocal growth of PTC.

Materials and methods: The main and control groups included patients with the category of malignant multifocal process T1-3mN0Mx (n=109) and unifocal T1-T3N0Mx (n=50) respectively, who underwent thyroidectomy with lymphadenectomy.Ultrasound characteristics of the nodes, tissue changes of the thyroid gland were taken into account.

Results: Fibrous changes can be considered as one of the risk factors of the presence of additional PTC lesion.

Discussion: There is no unambiguity in the definition of predictors of multifocal PTC growth.

Conclusions: No clear predictors of multifocal PTC have been identified. It is advisable to improve the quality of ultrasound, to focus on single-focus PTC in patients with fibrinous changes in the thyroid gland at normal levels of TSH.

Keywords: multifocality; predictors; thyroid carcinoma; ultrasound diagnostics.