m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis

Xiaohan Jiang; Ziyao Jin; Yuzhong Yang; Xiang Zheng; Shaohua Chen; Shuaijie Wang; Xuemei Zhang; Nanfang Qu

doi:10.3389/fonc.2023.1162300

m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis

Front Oncol. 2023 Apr 21:13:1162300. doi: 10.3389/fonc.2023.1162300. eCollection 2023.

Authors

Xiaohan Jiang¹, Ziyao Jin², Yuzhong Yang¹, Xiang Zheng¹, Shaohua Chen³, Shuaijie Wang¹, Xuemei Zhang⁴, Nanfang Qu⁵

Affiliations

¹ Department of Pathology, Affiliated Hospital of Guilin Medical University, Guilin, China.
² Key Laboratory of Oral Biomedical Research of Zhejiang Province, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Hangzhou, China.
³ Department of Breast and Thyroid Surgery, Liuzhou People's Hospital Affiliated to Guangxi Medical University, Liuzhou, China.
⁴ Department of Pathology, Liuzhou People's Hospital Affiliated to Guangxi Medical University, Liuzhou, China.
⁵ Department of Gastroenterology, Affiliated Hospital of Guilin Medical University, Guilin, China.

Abstract

N6-methyladenosine (m6A) is the most pervasive RNA modification in eukaryotic cells. The dynamic and reversible m6A modification of RNA plays a critical role in the occurrence and progression of tumors by regulating RNA metabolism, including translocation, mRNA stability or decay, pre-mRNA splicing, and lncRNA processing. Numerous studies have shown that m6A modification is involved in the development of various cancers. This review aims to summarize the significant role of m6A modification in the proliferation and tumorigenesis of CRC, as well as the potential of modulating m6A modification for tumor treatment. These findings may offer new therapeutic strategies for clinical implementation of m6A modification in CRC in the near future.

Keywords: N6-methyladenosine; RNA modification; colorectal cancer; proliferation; tumorigenesis.

Publication types

Review

Grants and funding

This study was supported by grants from the National Natural Science Foundation of China (82160108, 82060042, 81802478) and Guangxi Natural Science Foundation (2018GXNSFBA050042).