A novel 25-ferroptosis-related gene signature for the prognosis of gliomas

Xiaojiang Peng; Chun Liu; Jing Li; Zeqing Bao; Tao Huang; Lingfeng Zeng; Qixiong He; Daojin Xue

doi:10.3389/fonc.2023.1128278

A novel 25-ferroptosis-related gene signature for the prognosis of gliomas

Front Oncol. 2023 Apr 20:13:1128278. doi: 10.3389/fonc.2023.1128278. eCollection 2023.

Authors

Xiaojiang Peng¹, Chun Liu², Jing Li³, Zeqing Bao¹, Tao Huang⁴, Lingfeng Zeng⁵, Qixiong He¹, Daojin Xue⁴

Affiliations

¹ Zhaoqing Medical College, Zhaoqing, China.
² Department of Neurosurgery, Lianshui People's Hospital Affiliated to Kangda College of Nanjing Medical University, Huaian, China.
³ Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
⁴ Department of Neurosurgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
⁵ Department of Medicine, Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.

Abstract

Background: Ferroptosis is closely associated with cancer and is of great importance in the immune evasion of cancer. However, the relationship between ferroptosis and glioma is unclear.

Methods: We downloaded the expression profiles and clinical data of glioma from the GlioVis database and obtained the expression profiles of ferroptosis genes. A ferroptosis-related gene signature was developed for the prognosis of gliomas.

Results: We screened out prognostic ferroptosis genes, named ferroptosis-related genes, by the Cox regression method. Based on these genes, we used unsupervised clustering to obtain two different clusters; the principal component analysis algorithm was applied to determine the gene score of each patient, and then all the patients were classified into two subgroups. Results showed that there exist obvious differences in survival between different clusters and different gene score subgroups. The prognostic model constructed by the 25 ferroptosis-related genes was then evaluated to predict the clinicopathological features of immune activity in gliomas.

Conclusion: The ferroptosis-related genes play an important role in the malignant process of gliomas, potentially contributing to the development of prognostic stratification and treatment strategies.

Keywords: bioinformatic; ferroptosis; gene signature; gliomas; prognosis.

Grants and funding

This study was supported by the 13th Chaoyang Talent Project of Guangdong Provincial Hospital of Traditional Chinese Medicine (ZY2022YL28), the Startup Fund from Guangzhou Municipal Science and Technology Bureau (No. 202002030221), the Science and Technology Innovation Guidance Project of Zhaoqing Municipal Science and Technology Bureau (No. 2021040308025), and the 17th Bajian Talent Project of Guangdong Provincial Hospital of Traditional Chinese Medicine (BJ2022YL06).