Progeny Transfer Effects of Chitosan-Coated Cobalt Ferrite Nanoparticles

Md Salman Shakil; Md Forhad Uddin; Md Reaz Morshed; Md Simul Bhuiya; Morshed Alam; Md Sakib Hossen; Mahruba Sultana Niloy; Mohammad Mahfuz Ali Khan Shawan; Sheikh Manjura Hoque; Md Ashraful Hasan

doi:10.1021/acsomega.3c00148

Progeny Transfer Effects of Chitosan-Coated Cobalt Ferrite Nanoparticles

ACS Omega. 2023 Apr 19;8(17):15152-15159. doi: 10.1021/acsomega.3c00148. eCollection 2023 May 2.

Affiliations

¹ Department of Mathematics and Natural Sciences, Brac University, 66 Mohakhali, Dhaka 1212, Bangladesh.
² Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar 1342, Bangladesh.
³ Department of Biochemistry and Molecular Biology, Noakhali Science and Technology University, Noakhali 3814, Bangladesh.
⁴ Department of Biochemistry and Molecular Biology, Primeasia University, Banani 1213, Bangladesh.
⁵ Material Science Division, Atomic Energy Centre, Dhaka 1000, Bangladesh.

Abstract

Cobalt ferrite nanoparticles (CFNs) are promising materials for their enticing properties for different biomedical applications, including magnetic resonance imaging (MRI) contrast, drug carriers, biosensors, and many more. In our previous study, a chitosan-coated CFN (CCN) nanocomplex demonstrated potential as an MRI contrast dye by improving the biocompatibility of CFN. In this study, we report the progeny transfer effects of CCN following a single intravenous injection of CCN (20, 40, or 60 mg/kg) in pregnant albino Wistar rats. Biochemical and histological observation reveals that CCN is tolerated with respect to maternal organ functions (e.g., liver, kidney). Atomic absorption spectroscopy results showed that CCN or CCN-leached iron could cross the placental barrier and deposit in the fetus. Furthermore, this deposition accelerated lipid peroxidation in the placenta and fetus.