Fecal microbiota transplantation for Parkinson's disease using levodopa - carbidopa intestinal gel percutaneous endoscopic gastro-jejeunal tube

Vlada O Chernova; Elisabeth M Terveer; Joffrey van Prehn; Eduard J Kuijper; Josbert J Keller; Andrea E van der Meulen-de Jong; Martijn P Bauer; Jacobus J van Hilten; M Fiorella Contarino

doi:10.1016/j.parkreldis.2023.105410

Fecal microbiota transplantation for Parkinson's disease using levodopa - carbidopa intestinal gel percutaneous endoscopic gastro-jejeunal tube

Parkinsonism Relat Disord. 2023 Jun:111:105410. doi: 10.1016/j.parkreldis.2023.105410. Epub 2023 Apr 22.

Authors

Vlada O Chernova¹, Elisabeth M Terveer², Joffrey van Prehn², Eduard J Kuijper³, Josbert J Keller⁴, Andrea E van der Meulen-de Jong⁵, Martijn P Bauer⁶, Jacobus J van Hilten⁷, M Fiorella Contarino⁸

Affiliations

¹ Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands; Netherlands Donor Feces Bank, Leiden University Medical Center, Leiden, the Netherlands.
² Netherlands Donor Feces Bank, Leiden University Medical Center, Leiden, the Netherlands; Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
³ Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
⁴ Netherlands Donor Feces Bank, Leiden University Medical Center, Leiden, the Netherlands; Department of Gastroenterology and Hepatology, Leiden University Medical Center, the Netherlands; Department of Gastroenterology, Haaglanden Medical Center, The Hague, the Netherlands.
⁵ Department of Gastroenterology and Hepatology, Leiden University Medical Center, the Netherlands.
⁶ Department of General Internal Medicine and Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.
⁷ Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.
⁸ Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology, Haga Teaching Hospital, The Hague, the Netherlands. Electronic address: M.F.Contarino@lumc.nl.

PMID: 37150070
DOI: 10.1016/j.parkreldis.2023.105410

Abstract

We report a patient with a 5-year diagnosis of akinetic-rigid Parkinson's disease under treatment with Levodopa-Carbidopa Intestinal Gel therapy through a PEG-J tube due to motor complications, in which, in the context of a clinical study, we successfully and safely administered fecal microbiota transplant through a PEG-J.

Keywords: Carbidopa intestinal gel; Fecal microbiota transplantation; Levodopa; Microbiota; Parkinson's disease; Percutaneous endoscopic gastro-jejunal tube.

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antiparkinson Agents / therapeutic use
Carbidopa
Drug Combinations
Fecal Microbiota Transplantation
Gels / therapeutic use
Humans
Levodopa* / therapeutic use
Parkinson Disease* / drug therapy

Substances

Levodopa
Carbidopa
Antiparkinson Agents
Gels
Drug Combinations