Immune Dysregulation in Treatment-Resistant Depression: Precision Approaches to Treatment Selection and Development of Novel Treatments

Cherise R Chin Fatt; Taryn L Mayes; Madhukar H Trivedi

doi:10.1016/j.psc.2023.02.010

Immune Dysregulation in Treatment-Resistant Depression: Precision Approaches to Treatment Selection and Development of Novel Treatments

Psychiatr Clin North Am. 2023 Jun;46(2):403-413. doi: 10.1016/j.psc.2023.02.010.

Authors

Cherise R Chin Fatt¹, Taryn L Mayes¹, Madhukar H Trivedi²

Affiliations

¹ Center for Depression Research and Clinical Care, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9086, USA.
² Center for Depression Research and Clinical Care, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9086, USA. Electronic address: madhukar.trivedi@utsouthwestern.edu.

PMID: 37149353
DOI: 10.1016/j.psc.2023.02.010

Abstract

Owing to the link between immune dysfunction and treatment-resistant depression (TRD) and the overwhelming evidence that the immune dysregulation and major depressive disorder (MDD) are associated with each other, using immune profiles to identify the biological distinct subgroup may be the step forward to understanding MDD and TRD. This report aims to briefly review the role of inflammation in the pathophysiology of depression (and TRD in particular), the role of immune dysfunction to guide precision medicine, tools used to understand immune function, and novel statistical techniques.

Keywords: Immune function; Precision medicine; Treatment-resistant depression.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Depression
Depressive Disorder, Major* / drug therapy
Depressive Disorder, Treatment-Resistant* / drug therapy
Humans
Precision Medicine