Cytomegalovirus in Pregnancy

Dana Canfield; Lauryn Gabby; Elmira Vaziri Fard; Cynthia Gyamfi-Bannerman

doi:10.1016/j.ogc.2023.02.002

Cytomegalovirus in Pregnancy

Obstet Gynecol Clin North Am. 2023 Jun;50(2):263-277. doi: 10.1016/j.ogc.2023.02.002.

Authors

Dana Canfield¹, Lauryn Gabby¹, Elmira Vaziri Fard², Cynthia Gyamfi-Bannerman³

Affiliations

¹ Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, CA, USA.
² Department of Pathology and Lab Medicine, University of California, San Diego, CA, USA.
³ Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, CA, USA. Electronic address: cgyamfibannerman@health.ucsd.edu.

PMID: 37149309
DOI: 10.1016/j.ogc.2023.02.002

Abstract

Cytomegalovirus is a pervasive DNA herpesvirus that, while clinically insignificant to an immunocompetent adult host, can cause significant morbidity to a congenitally infected fetus. Although detection is often possible with several common ultrasonographic markers and good diagnostic accuracy using polymerase chain reaction testing of amniotic fluid, there are no proven prenatal prevention or antenatal treatment options. Therefore, universal screening is not currently recommended in pregnancy. Strategies that have been studied in the past include immunoglobulins, antivirals, and the development of a vaccine. In this review, we will further discuss the themes above, along with future direction for prevention and treatment.

Keywords: Cytomegalovirus in pregnancy; Screening for congenital cytomegalovirus; Ultrasonographic findings.

Publication types

Review

MeSH terms

Adult
Amniotic Fluid
Cytomegalovirus / genetics
Cytomegalovirus Infections* / diagnosis
Female
Humans
Pregnancy
Pregnancy Complications, Infectious* / therapy
Prenatal Diagnosis