Association between gout and abdominal aortic aneurysm

Jen-Chun Wang; Shih-Hung Tsai; Wu-Chien Chien; Chi-Hsiang Chung; Shing-Jong Lin; Yung-Tai Chen; Po-Hsun Huang

doi:10.1016/j.jjcc.2023.04.022

Association between gout and abdominal aortic aneurysm

J Cardiol. 2023 Oct;82(4):274-278. doi: 10.1016/j.jjcc.2023.04.022. Epub 2023 May 4.

Authors

Jen-Chun Wang¹, Shih-Hung Tsai², Wu-Chien Chien³, Chi-Hsiang Chung³, Shing-Jong Lin⁴, Yung-Tai Chen⁵, Po-Hsun Huang⁶

Affiliations

¹ Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
² Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address: tsaishihung@ndmctsgh.edu.tw.
³ Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; School of Public Health, National Defense Medical Center, Taipei, Taiwan; Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan.
⁴ Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan; Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan.
⁵ Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
⁶ Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Critical Care Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address: huangbsvgh@gmail.com.

PMID: 37149284
DOI: 10.1016/j.jjcc.2023.04.022

Abstract

Background: Previous studies have shown an association between hyperuricemia and microvascular diseases, but the association between uric acid and abdominal aortic aneurysm (AAA) remains unclear. The aim of this study was to determine the relationship between gout and AAA.

Methods: A population-based cohort study was conducted to validate the association between gout and AAA formation. The outcome in this study was the cumulative incidence of AAA in patients with or without gout during the 14-year follow-up period.

Results: Our analysis included 121,236 patients with gout and 121,236 propensity score-matched controls from the National Health Insurance Research Database in Taiwan. Compared to the controls, patients who had gout exhibited a significantly increased incidence of AAA development [adjusted hazard ratio (HR) = 2.465, p < 0.001]. We also found that patients who were treated with anti-gout medications had a significantly lower risk of being diagnosed with an AAA than patients who were not treated with anti-gout medications (adjusted HR = 0.489, p < 0.001).

Conclusions: We have provided clinical evidence that gout is associated with the development of AAA.

Keywords: Abdominal aortic aneurysm; Hyperuricemia; Uric acid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aortic Aneurysm, Abdominal* / epidemiology
Aortic Aneurysm, Abdominal* / etiology
Cohort Studies
Gout* / complications
Gout* / drug therapy
Gout* / epidemiology
Humans
Hyperuricemia* / complications
Hyperuricemia* / epidemiology
Retrospective Studies
Risk Factors