Biomolecular condensates tunes immune signaling at the Host-Pathogen interface

Yansong Miao; Xiangfu Guo; Kexin Zhu; Wenting Zhao

doi:10.1016/j.pbi.2023.102374

Biomolecular condensates tunes immune signaling at the Host-Pathogen interface

Curr Opin Plant Biol. 2023 Aug:74:102374. doi: 10.1016/j.pbi.2023.102374. Epub 2023 May 4.

Authors

Yansong Miao¹, Xiangfu Guo², Kexin Zhu³, Wenting Zhao⁴

Affiliations

¹ School of Biological Sciences, Nanyang Technological University, 637551, Singapore; Institute for Digital Molecular Analytics and Science, Nanyang Technological University, 636921, Singapore. Electronic address: yansongm@ntu.edu.sg.
² School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 70 Nanyang Drive, 637457, Singapore.
³ School of Biological Sciences, Nanyang Technological University, 637551, Singapore.
⁴ School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 70 Nanyang Drive, 637457, Singapore; Institute for Digital Molecular Analytics and Science, Nanyang Technological University, 636921, Singapore.

PMID: 37148673
DOI: 10.1016/j.pbi.2023.102374

Abstract

Membraneless organelles participate in diverse spatiotemporal regulation of cellular signal transduction by recruiting necessary signaling factors. During host-pathogen interactions, the plasma membrane (PM) at the interface between the plant and microbes serves as a central platform for forming multicomponent immune signaling hubs. The macromolecular condensation of the immune complex and regulators is important in regulating immune signaling outputs regarding strength, timing, and crosstalk between signaling pathways. This review discusses mechanisms that regulate specific and crosstalk of plant immune signal transduction pathways through macromolecular assembly and condensation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biomolecular Condensates*
Cell Membrane
Organelles / physiology
Plants
Signal Transduction*