Doxorubicin inhibits phosphatidylserine decarboxylase and confers broad-spectrum antifungal activity

New Phytol. 2023 Jul;239(1):255-270. doi: 10.1111/nph.18944. Epub 2023 May 6.

Abstract

As phospholipids of cell membranes, phosphatidylethanolamine (PE) and phosphatidylserine (PS) play crucial roles in glycerophospholipid metabolism. Broadly, some phospholipid biosynthesis enzymes serve as potential fungicide targets. Therefore, revealing the functions and mechanism of PE biosynthesis in plant pathogens would provide potential targets for crop disease control. We performed analyses including phenotypic characterizations, lipidomics, enzyme activity, site-directed mutagenesis, and chemical inhibition assays to study the function of PS decarboxylase-encoding gene MoPSD2 in rice blast fungus Magnaporthe oryzae. The Mopsd2 mutant was defective in development, lipid metabolism, and plant infection. The PS level increased while PE decreased in Mopsd2, consistent with the enzyme activity. Furthermore, chemical doxorubicin inhibited the enzyme activity of MoPsd2 and showed antifungal activity against 10 phytopathogenic fungi including M. oryzae and reduced disease severity of two crop diseases in the field. Three predicted doxorubicin-interacting residues are important for MoPsd2 functions. Our study demonstrates that MoPsd2 is involved in de novo PE biosynthesis and contributes to the development and plant infection of M. oryzae and that doxorubicin shows broad-spectrum antifungal activity as a fungicide candidate. The study also implicates that bacterium Streptomyces peucetius, which biosynthesizes doxorubicin, could be potentially used as an eco-friendly biocontrol agent.

Keywords: Pyricularia oryzae; fungicide; lipid metabolism; pathogenesis; phosphatidylethanolamine; rice blast.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology
  • Carboxy-Lyases*
  • Fungicides, Industrial* / pharmacology
  • Magnaporthe* / genetics
  • Oryza* / microbiology
  • Plant Diseases / microbiology

Substances

  • Antifungal Agents
  • Fungicides, Industrial
  • phosphatidylserine decarboxylase
  • Carboxy-Lyases