Cu-MOFs based photocatalyst triggered antibacterial platform for wound healing: 2D/2D Schottky junction and DFT calculation

Shi-Xian Guan; Tao Xu; Jian-Yong Zhang; You-Guo Luo; Xingwu Zhai; Na Zhang; Yong-Zheng Fang; Qin-Fei Ke

doi:10.1016/j.jhazmat.2023.131531

Cu-MOFs based photocatalyst triggered antibacterial platform for wound healing: 2D/2D Schottky junction and DFT calculation

J Hazard Mater. 2023 Jul 15:454:131531. doi: 10.1016/j.jhazmat.2023.131531. Epub 2023 Apr 27.

Authors

Shi-Xian Guan¹, Tao Xu¹, Jian-Yong Zhang², You-Guo Luo¹, Xingwu Zhai³, Na Zhang⁴, Yong-Zheng Fang⁵, Qin-Fei Ke⁶

Affiliations

¹ School of Materials Science and Engineering, Shanghai Institute of Technology, Shanghai 201418, PR China.
² School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, PR China.
³ Hefei National Laboratory for Physical Science at the Microscale, Department of Applied Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
⁴ School of Materials Science and Engineering, Shanghai Institute of Technology, Shanghai 201418, PR China. Electronic address: nzhang@sit.edu.cn.
⁵ School of Materials Science and Engineering, Shanghai Institute of Technology, Shanghai 201418, PR China; Shanghai Engineering Research Center of Photodetection Materials and Devices, Shanghai Institute of Technology, Shanghai 200235, PR China. Electronic address: fyz1003@sina.com.
⁶ School of Materials Science and Engineering, Shanghai Institute of Technology, Shanghai 201418, PR China. Electronic address: kqf@sit.edu.cn.

PMID: 37146334
DOI: 10.1016/j.jhazmat.2023.131531

Abstract

Herein, we developed a multimodal antibacterial nanoplatform via synergism effect including knife-effect, photothermal, photocatalytic induced reactive oxygen species (ROS), and Cu²⁺ inherent attribute. Typically, 0.8-TC/Cu-NS possesses higher photothermal property with the higher photothermal conversion efficiency of 24% and the moderate temperature up to 97 °C. Meanwhile, 0.8-TC/Cu-NS exhibits the more active ROS, ¹O₂ and ·O₂^-. Hence, 0.8-TC/Cu-NS possesses best antibacterial properties against S. aureus and E. coli in vitro with efficiency of 99.94%/99.97% under near-infrared (NIR) light, respectively. In the therapeutic practical use for wound healing of Kunming mice, this system exhibits outstanding curing capacity and good biocompatibility. Based on the electron configuration measurement and density functional theory (DFT) simulation, it is confirmed that the electrons on CB of Cu-TCPP flow fleetingly to MXene trough the interface, with redistribution of charge and band upward bending over Cu-TCPP. As a result, the self-assembled 2D/2D interfacial Schottky junction have made great favor to accelerate photogenerated charges mobility, hamper charge recombination, and increases the photothermal/photocatalytic activity. This work gives us a hint to mostly design the multimodal synergistic nanoplatform under NIR light in biological applications without drug resistance.

Keywords: 2D/2D Schottky junction; Antibacterial; DFT calculation; Photocatalysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / pharmacology
Density Functional Theory
Escherichia coli*
Mice
Reactive Oxygen Species / pharmacology
Staphylococcus aureus*
Wound Healing

Substances

Reactive Oxygen Species
MXene
Anti-Bacterial Agents

Supplementary concepts

Kunming mice