Mouse Model of Latent Cryptococcal Infection and Reactivation

Ko Sato; Kazuyoshi Kawakami

doi:10.1007/978-1-0716-3199-7_6

Mouse Model of Latent Cryptococcal Infection and Reactivation

Methods Mol Biol. 2023:2667:87-98. doi: 10.1007/978-1-0716-3199-7_6.

Authors

Ko Sato^{1

2}, Kazuyoshi Kawakami^{3

4}

Affiliations

¹ Department of Medical Microbiology, Mycology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. ko-sato@med.tohoku.ac.jp.
² Department of Intelligent Network for Infection Control, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. ko-sato@med.tohoku.ac.jp.
³ Department of Medical Microbiology, Mycology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
⁴ Department of Intelligent Network for Infection Control, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

PMID: 37145277
DOI: 10.1007/978-1-0716-3199-7_6

Abstract

AbstractCryptococcus neoformans is an opportunistic fungal pathogen that frequently causes fatal meningoencephalitis in patients with impaired immune responses. This fungus, an intracellularly growing microbe, evades host immunity, leading to a latent infection (latent C. neoformans infection: LCNI), and cryptococcal disease is developed by its reactivation when host immunity is suppressed. Elucidation of the pathophysiology of LCNI is difficult due to the lack of mouse models. Here we show the established methods for LCNI and reactivation.

Keywords: Cryptococcus neoformans; Latent infection; Mouse model; Reactivation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cryptococcus neoformans*
Disease Models, Animal
Mice