Changes in the metabolism of biogenic amines in alcoholism--especially regarding CSF monoamine metabolites and serum DBH activity

Alcohol Clin Exp Res. 1979 Jan;3(1):24-7. doi: 10.1111/j.1530-0277.1979.tb04761.x.

Abstract

Concentrations of the major metabolites of biogenic amines in cerebrospinal fluid and activity of serum dopamine-beta-hydroxylase in abstinent alcoholics were measured, suggesting that withdrawal symptoms of alcoholics were based on the abnormality of serotonin and dopamine metabolism in the body.

MeSH terms

  • Adult
  • Aged
  • Alcoholism / metabolism*
  • Biogenic Amines / cerebrospinal fluid
  • Biogenic Amines / metabolism*
  • Dopamine beta-Hydroxylase / blood*
  • Female
  • Homovanillic Acid / cerebrospinal fluid
  • Humans
  • Hydroxyindoleacetic Acid / cerebrospinal fluid
  • Male
  • Middle Aged
  • Substance Withdrawal Syndrome / metabolism
  • Time Factors

Substances

  • Biogenic Amines
  • Hydroxyindoleacetic Acid
  • Dopamine beta-Hydroxylase
  • Homovanillic Acid