SARS-CoV-2 suppression depending on the pH of graphene oxide nanosheets

Md Saidul Islam; Masahiro Fukuda; Md Jakir Hossain; Nurun Nahar Rabin; Ryuta Tagawa; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Yoshihiro Sekine; Terumasa Ikeda; Shinya Hayami

doi:10.1039/d3na00084b

SARS-CoV-2 suppression depending on the pH of graphene oxide nanosheets

Nanoscale Adv. 2023 Mar 10;5(9):2413-2417. doi: 10.1039/d3na00084b. eCollection 2023 May 2.

Authors

Md Saidul Islam^{1

2}, Masahiro Fukuda², Md Jakir Hossain^{3

4}, Nurun Nahar Rabin^{1

2}, Ryuta Tagawa¹, Mami Nagashima⁵, Kenji Sadamasu⁵, Kazuhisa Yoshimura⁵, Yoshihiro Sekine⁶, Terumasa Ikeda⁴, Shinya Hayami^{1

2

7}

Affiliations

¹ Department of Chemistry, Faculty of Advanced Science and Technology, Kumamoto University 2-39-1 Kurokami Kumamoto 860-8555 Japan hayami@kumamoto-u.ac.jp.
² Institute of Industrial Nanomaterials, Kumamoto University 2-39-1 Kurokami, Chuo-ku Kumamoto 860-8555 Japan.
³ Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus Infection, Kumamoto University 2-2-1 Honjo Kumamoto 860-0811 Japan.
⁴ Graduate School of Medical Sciences, Kumamoto University Kumamoto 860-0811 Japan.
⁵ Tokyo Metropolitan Institute of Public Health Tokyo Japan.
⁶ Priority Organization for Innovation and Excellence, Kumamoto University 2-39-1 Kurokami, Chuo-ku Kumamoto 860-8555 Japan.
⁷ International Research Center for Agricultural and Environmental Biology (IRCAEB) 2-39-1 Kurokami, Chuo-ku Kumamoto 860-8555 Japan.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inactivation of pH-dependent graphene oxide (GO) nanosheets is presented. The observed virus inactivation using an authentic virus (Delta variant) and different GO dispersions at pH 3, 7, and 11 suggests that the higher pH of the GO dispersion yields a better performance compared to that of GO at neutral or lower pH. The current findings can be ascribed to the pH-driven functional group change and the overall charge of GO, favorable for the attachment between GO nanosheets and virus particles.