Increase in conduction velocity in myelinated nerves due to stretch - An experimental verification

Sabrina Sharmin; Mohammad Abu Sayem Karal; Zaid Bin Mahbub; Khondkar Siddique-E Rabbani

doi:10.3389/fnins.2023.1084004

Increase in conduction velocity in myelinated nerves due to stretch - An experimental verification

Front Neurosci. 2023 Apr 17:17:1084004. doi: 10.3389/fnins.2023.1084004. eCollection 2023.

Authors

Sabrina Sharmin^{1

2}, Mohammad Abu Sayem Karal¹, Zaid Bin Mahbub³, Khondkar Siddique-E Rabbani⁴

Affiliations

¹ Department of Physics, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh.
² Department of Arts and Sciences, Ahsanullah University of Science and Technology, Dhaka, Bangladesh.
³ Department of Mathematics and Physics, North South University, Dhaka, Bangladesh.
⁴ Department of Biomedical Physics and Technology, University of Dhaka, Dhaka, Bangladesh.

Abstract

Background: Based on published experimental evidence, a recent publication revealed an anomalous phenomenon in nerve conduction: for myelinated nerves the nerve conduction velocity (NCV) increases with stretch, which should have been the opposite according to existing concepts and theories since the diameter decreases on stretching. To resolve the anomaly, a new conduction mechanism for myelinated nerves was proposed based on physiological changes in the nodal region, introducing a new electrical resistance at the node. The earlier experimental measurements of NCV were performed on the ulnar nerve at different angles of flexion, focusing at the elbow region, but left some uncertainty for not reporting the lengths of nerve segments involved so that the magnitudes of stretch could not be estimated.

Aims: The aim of the present study was to relate NCV of myelinated nerves with different magnitudes of stretch through careful measurements.

Method: Essentially, we duplicated the earlier published NCV measurements on ulnar nerves at different angles of flexion but recording appropriate distances between nerve stimulation points on the skin carefully and assuming that the lengths of the underlying nerve segment undergoes the same percentages of changes as that on the skin outside.

Results: We found that the percentage of nerve stretch across the elbow is directly proportional to the angle of flexion and that the percentage increase in NCV is directly proportional to the percentage increase in nerve stretch. Page's L Trend test also supported the above trends of changes through obtained p values.

Discussion: Our experimental findings on myelinated nerves agree with those of some recent publications which measured changes in CV of single fibres, both myelinated and unmyelinated, on stretch. Analyzing all the observed results, we may infer that the new conduction mechanism based on the nodal resistance and proposed by the recent publication mentioned above is the most plausible one to explain the increase in CV with nerve stretch. Furthermore, interpreting the experimental results in the light of the new mechanism, we may suggest that the ulnar nerve at the forearm is always under a mild stretch, with slightly increased NCV of the myelinated nerves.

Keywords: elbow flexion; myelinated nerve; nerve conduction velocity; nerve stretch; nodes of Ranvier; ulnar nerve.