Post COVID-19 Vaccination Side Effects and Associated Factors Among Vaccinated Clients in Bahir Dar City, Ethiopia

Ebrahim Abdela Siraj; Ashagrachew Tewabe Yayehrad; Zewdu Yilma; Tamyalew Getahun; Mequannent Sharew Melaku; Gizachew Kassahun Bizuneh; Zemene Demelash Kifle; Dawit Kumilachew Yimenu

doi:10.1177/23779608231172358

Post COVID-19 Vaccination Side Effects and Associated Factors Among Vaccinated Clients in Bahir Dar City, Ethiopia

SAGE Open Nurs. 2023 Apr 27:9:23779608231172358. doi: 10.1177/23779608231172358. eCollection 2023 Jan-Dec.

Authors

Ebrahim Abdela Siraj¹, Ashagrachew Tewabe Yayehrad¹, Zewdu Yilma¹, Tamyalew Getahun², Mequannent Sharew Melaku³, Gizachew Kassahun Bizuneh⁴, Zemene Demelash Kifle⁵, Dawit Kumilachew Yimenu⁶

Affiliations

¹ Department of Pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
² Addis Alem Primary Hospital, Amhara Regional Health Beuro, Bahir Dar, Ethiopia.
³ Department of Health Informatics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
⁴ Department of Pharmacognosy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
⁵ Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
⁶ Discipline of Pharmacy, School of Allied Health, The University of Western Australia.

Abstract

Introduction: The lack of local side effect profiles for vaccines could hinder vaccination uptake. Since all COVID-19 vaccines are brand-new medications, it is crucial to keep track of any safety related concern.

Objective: This study is aimed to investigate post-vaccination side effects of COVID-19 vaccines and associated factors in Bahir Dar city.

Method: An institutional-based cross-sectional study was conducted among vaccinated clients. A simple random and a systematic random sampling method were used to select the health facilities and the participants, respectively. Bi-variable and multivariable binary logistic regression analyses were executed with odds ratio at 95% confidence intervals at p < .05.

Results: A total of 72(17.4%) participants reported at least one side effect following vaccination. The proportion prevalence was higher after the first dose than that of the second dose and the difference was also found to be statistically significant. In the multivariable logistic regression analysis female participants (AOR = 3.39, 95% CI = 1.53, 7.52), participants with a history of regular medication use (AOR = 3.34, 95% CI = 1.52, 7.33), participants aged 55 and above (AOR = 2.93, 95% CI = 1.23, 7.01), and participants who had taken only the first dose (AOR = 14.81, 95% CI = 6.40, 34.31) were more likely to develop side effects for COVID 19 vaccination compared to their counterparts.

Conclusion: A significant number (17.4%) of participants reported at least one side effect following vaccination. Sex, medication, occupation, age, and type of vaccination dose were factors statistically associated with the reported side effects.

Keywords: COVID 19; side effects; vaccination; vaccine dose.