Trends in cutaneous squamous cell carcinoma on the lip incidence and mortality in the United States, 2000-2019

Jin Zhang; Quyang Yang; Jinyan Wu; Ruoyue Yuan; Xiansheng Zhao; Yue Li; Xiujun Cheng; Baojin Wu; Ningwen Zhu

doi:10.3389/fonc.2023.1111907

Trends in cutaneous squamous cell carcinoma on the lip incidence and mortality in the United States, 2000-2019

Front Oncol. 2023 Apr 17:13:1111907. doi: 10.3389/fonc.2023.1111907. eCollection 2023.

Authors

Jin Zhang¹, Quyang Yang¹, Jinyan Wu¹, Ruoyue Yuan¹, Xiansheng Zhao¹, Yue Li¹, Xiujun Cheng¹, Baojin Wu², Ningwen Zhu¹

Affiliations

¹ Department of Dermatology, Shanghai Institute of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
² Huashan Hospital, Fudan University, Shanghai, China.

Abstract

Objective: This study provided a systematic analysis of the trend in incidence and incidence-based mortality for cutaneous squamous cell carcinoma (cSCC) on the lips in the USA using demographic characteristics from the Surveillance, Epidemiology, and End Results (SEER) database.

Methods: Patients diagnosed with cSCC on the lips between 2000 and 2019 from the 17 registries of the USA were identified. Incidence and incidence-based mortality rates were analyzed using SEER*Stat 8.4.0.1 software. This paper calculated incidence rates and incidence-based mortality rates by 100,000 person-years for sex, age, race, SEER registries, median household income ($/year), rural-urban distribution, and primary site. The annual percent changes (APC) in incidence and incidence-based mortality rates were then calculated using joinpoint regression software.

Results: Among 8,625 patients diagnosed with cSCC on the lips from 2000 to 2019, men (74.67%), white (95.21%), and 60-79 years old were the most common population, and 3,869 deaths from cSCC on the lips occurred. The overall incidence of cSCC on the lips was 0.516 per 100,000 person-years. cSCC on the lip incidence rates were highest among men, white, and patients aged 60-79 years old. cSCC on the lip incidence rates decreased by 3.210%/year over the study period. The incidence of cSCC on the lips has been decreasing in all sexes, ages, high- or low-income households, and urban or rural patients. The overall incidence-based mortality rate of cSCC on the lips during 2000-2019 was 0.235 per 100,000 person-years. cSCC on the lip incidence-based mortality rates were highest among men, whites, and people older than 80 years old. cSCC on the lip incidence-based mortality increased by 4.975%/year over the study period. cSCC on the lip incidence-based mortality rates increased for all sexes, races, ages, primary sites, high- or low-income households, and urban or rural patients during the study period.

Conclusion: Among patients in the USA diagnosed with cSCC on the lips from 2000 to 2019, the overall incidence decreased by 3.210% annually, and incidence-based mortality increased by 4.975%/year. These findings update and supplement the epidemiological information of cSCC on the lips in the USA.

Keywords: annual percent changes (APC); cSCC on the lips; cutaneous squamous cell carcinoma (cSCC); incidence; incidence-based mortality.

Grants and funding

This work was supported by grants from the National Key R&D Program of China (2021YFA1101100), the National Natural Science Foundation of China (Grant No. 8217081123), and the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16040400).