A Genomic Perspective on the Near-term Impact of Doxycycline Post-exposure Prophylaxis on Neisseria gonorrhoeae Antimicrobial Resistance

Clin Infect Dis. 2023 Sep 11;77(5):788-791. doi: 10.1093/cid/ciad279.

Abstract

Pre-existing tetracycline resistance in Neisseria gonorrhoeae limits the effectiveness of post-exposure prophylaxis (PEP) with doxycycline against gonorrhea, and selection for tetracycline resistance may influence prevalence of multi-drug resistant strains. Using genomic and antimicrobial susceptibility data from N. gonorrhoeae, we assessed the near-term impact of doxycycline PEP on N. gonorrhoeae resistance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Doxycycline / pharmacology
  • Doxycycline / therapeutic use
  • Drug Resistance, Bacterial / genetics
  • Genomics
  • Gonorrhea* / drug therapy
  • Gonorrhea* / epidemiology
  • Gonorrhea* / prevention & control
  • Humans
  • Microbial Sensitivity Tests
  • Neisseria gonorrhoeae* / genetics
  • Post-Exposure Prophylaxis
  • Tetracycline / pharmacology

Substances

  • Anti-Bacterial Agents
  • Doxycycline
  • Tetracycline