G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

Thian-Sze Wong; Guangzhi Li; Shiliang Li; Wei Gao; Geng Chen; Shiyi Gan; Manzhan Zhang; Honglin Li; Song Wu; Yang Du

doi:10.1038/s41392-023-01427-2

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

Signal Transduct Target Ther. 2023 May 3;8(1):177. doi: 10.1038/s41392-023-01427-2.

Authors

Thian-Sze Wong^#^{1

2}, Guangzhi Li^#³, Shiliang Li^#^{4

5}, Wei Gao^{1

5}, Geng Chen¹, Shiyi Gan¹, Manzhan Zhang^{4

5}, Honglin Li^{6

7}, Song Wu^{8

9}, Yang Du¹⁰

Affiliations

¹ Kobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, 518172, Shenzhen, Guangdong, China.
² School of Medicine, Tsinghua University, 100084, Beijing, China.
³ Institute of Urology, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, 518000, Shenzhen, Guangdong, China.
⁴ Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 200237, Shanghai, China.
⁵ Innovation Center for AI and Drug Discovery, East China Normal University, 200062, Shanghai, China.
⁶ Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 200237, Shanghai, China. hlli@ecust.edu.cn.
⁷ Innovation Center for AI and Drug Discovery, East China Normal University, 200062, Shanghai, China. hlli@ecust.edu.cn.
⁸ Institute of Urology, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, 518000, Shenzhen, Guangdong, China. wusong@szu.edu.cn.
⁹ Department of Urology, South China Hospital, Health Science Center, Shenzhen University, 518116, Shenzhen, Guangdong, China. wusong@szu.edu.cn.
¹⁰ Kobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong, 518172, Shenzhen, Guangdong, China. yangdu@cuhk.edu.cn.

^# Contributed equally.

Abstract

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the diseases are resulting from heterogeneous biological, genetic, and environmental factors. Nevertheless, the increasing understanding of G protein-coupled receptor (GPCR) opens a new possibility in drug discovery. Harnessing our knowledge of molecular mechanisms and structural information of GPCRs will be advantageous for developing effective drugs. This review provides an overview of the role of GPCRs in various neurodegenerative and psychiatric diseases. Besides, we highlight the emerging opportunities of novel GPCR targets and address recent progress in GPCR drug development.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Drug Discovery
Humans
Mental Disorders* / genetics
Neurodegenerative Diseases* / genetics
Receptors, G-Protein-Coupled / chemistry
Receptors, G-Protein-Coupled / genetics

Substances

Receptors, G-Protein-Coupled