CD83+ B cells alleviate uveitis through inhibiting DCs by sCD83

Meng Feng; Xin Wang; Shuping Zhou; Minghao Li; Tingting Liu; Xunbin Wei; Wei Lin

doi:10.1111/imm.13654

CD83⁺ B cells alleviate uveitis through inhibiting DCs by sCD83

Immunology. 2023 Sep;170(1):134-153. doi: 10.1111/imm.13654. Epub 2023 May 3.

Authors

Meng Feng^{1

2

3}, Xin Wang^{4

5}, Shuping Zhou^{1

2

3}, Minghao Li^{1

2

3}, Tingting Liu⁶, Xunbin Wei^{7

8

9

10

11}, Wei Lin^{1

2

3}

Affiliations

¹ Department of Rheumatology and Autoimmunology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
² School of Clinical and Basic Medicine, Shandong First Medical University &Shandong Academy of Medical Sciences, Jinan, China.
³ Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Medicine and Health Key Laboratory of Rheumatism, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
⁴ Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, China.
⁵ Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application, Jinan, China.
⁶ Shandong Eye Hospital, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
⁷ Biomedical Engineering Department, Peking University, Beijing, China.
⁸ School of Biomedical Engineering, Anhui Medical University, Hefei, China.
⁹ Institute of Medical Technology, Peking University Health Science Center, Beijing, China.
¹⁰ Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China.
¹¹ International Cancer Institute, Peking University, Beijing, China.

PMID: 37137669
DOI: 10.1111/imm.13654

Abstract

Soluble CD83 (sCD83) exerts immunosuppressive functions in many autoimmune diseases, including experimental autoimmune uveitis (EAU), but the cells and mechanisms involved are unclear. This study showed that CD83⁺ B cells were the main sources of sCD83. They alleviated the symptoms of EAU and decreased the percentage of T cells and DCs in the eyes and lymph nodes. These CD83⁺ B cells decreased IL-1β, IL-18 and IFN-γ secretion by DCs through sCD83. sCD83 interacted with GTPase Ras-related protein (Rab1a) in DCs to promote Rab1a accumulation in autolysosomes and inhibit mTORC1 phosphorylation and NLRP3 expression. Hence, CD83⁺ B cells play a regulatory role in EAU by secreting sCD83. The lack of regulation of CD83⁺ B cells might be an important factor leading to hyperimmune activation in patients with autoimmune uveitis. CD83⁺ B cells suppress activated DCs in uveitis, indicating the potential therapeutic role of CD83⁺ B cells in uveitis.

Keywords: CD83+ B cells; DCs; Rab1a; autoimmune uveitis; immunoregulation; sCD83.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autoimmune Diseases*
B-Lymphocytes
Biological Transport
Eye
Humans
Uveitis*