The authors retracted this paper (Yu.A. Gladilina, A.N. Shishparenok, D.D. Zhdanov (2023) "Approaches for improving L-asparaginase expression in heterologous systems", Biomeditsinskaya Khimiya, 2023, 69(1), 19-38. DOI: 10.18097/PBMC20236901019) from the first issue the journal Biomeditsinskaya Khimiya (2023). Their decision is explained by identification of errors and inconsistences in the interpretation and citation of literature data recognized after the publication, which question correctness of important points considered in the review.