Activation of excitatory glycine NMDA receptors: At the mercy of a whimsical GluN1 subunit

J Gen Physiol. 2023 Jun 5;155(6):e202313391. doi: 10.1085/jgp.202313391. Epub 2023 May 3.

Authors

Miaomiao He^{1

2

3}, Lonnie P Wollmuth^{2

4

3}

Affiliations

¹ Graduate Program in Biochemistry and Structural Biology Stony Brook University , Stony Brook, NY, USA.
² Center for Nervous System Disorders, Stony Brook University , Stony Brook, NY, USA.
³ Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, USA.
⁴ Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, USA.

Abstract

Glycine-gated NMDA receptors contribute to brain functions and disorders. Rouzbeh et al. shed light on their odd pharmacology.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Binding Sites
Glycine
Receptors, Glycine*
Receptors, N-Methyl-D-Aspartate* / metabolism

Substances

Receptors, Glycine
Receptors, N-Methyl-D-Aspartate
Glycine

Grants and funding

R01 NS088479/NS/NINDS NIH HHS/United States