OPTN/SRTR 2021 Annual Data Report: Vascularized Composite Allograft

J Andres Hernandez; Guiliano Testa; Hani I Naga; Kaylyn B Pogson; Jonathan M Miller; Sarah E Booker; Jesse Howell; Kelley Poff; Liza Johannesson; Ajay K Israni; Jon J Snyder; Linda C Cendales

doi:10.1016/j.ajt.2023.02.012

OPTN/SRTR 2021 Annual Data Report: Vascularized Composite Allograft

Am J Transplant. 2023 Feb;23(2 Suppl 1):S523-S545. doi: 10.1016/j.ajt.2023.02.012.

Authors

Affiliations

¹ Department of Surgery, Duke University, Durham, NC.
² Baylor University Medical Center, Dallas, TX.
³ School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
⁴ Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN; Department of Medicine, Hennepin Healthcare, University of Minnesota, Minneapolis, MN.
⁵ Organ Procurement and Transplantation Network, United Network for Organ Sharing, Richmond, VA.
⁶ Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN; Department of Medicine, Hennepin Healthcare, University of Minnesota, Minneapolis, MN; Department of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.

PMID: 37132342
DOI: 10.1016/j.ajt.2023.02.012

Abstract

Year 2020 marked the first OPTN/SRTR Annual Data Report that included a chapter on vascularized composite allograft (VCA), which encompassed reviews of data collected between 2014 (when VCA was included in the Final Rule) and 2020. The present Annual Data Report shows that the number of VCA recipients in the United States continues to be small and trended downward in 2021. While data continue to be limited by sample size, trends continue to show a predominance in White, young/middle-aged, male recipients. Similar to the 2020 report, eight uterus and one non-uterus VCA graft failures were reported from 2014 through 2021. Critical to advancement of VCA transplantation will be the standardization of definitions, protocols, and outcome measures for the different VCA types. Like intestinal transplants, it is likely that VCA transplants will be concentrated and performed at referral transplant centers.

Keywords: Abdominal wall transplant; face transplant; multiorgan transplant; upper limb transplant; vascularized composite allograft (VCA).

MeSH terms

Composite Tissue Allografts* / transplantation
Humans
Male
Middle Aged
Transplants*
United States
Vascularized Composite Allotransplantation*