Association of Serum Uric Acid Level with Risk of Abdominal Aortic Calcification: A Large Cross-Sectional Study

Tao Liu; Ronghua Zuo; Jia Song; Jia Wang; Zhijian Zhu; Lifang Sun; Shasha Wang; Baoyin Li; Yesheng Pan; Bing Wang

doi:10.2147/JIR.S404668

Association of Serum Uric Acid Level with Risk of Abdominal Aortic Calcification: A Large Cross-Sectional Study

J Inflamm Res. 2023 Apr 26:16:1825-1836. doi: 10.2147/JIR.S404668. eCollection 2023.

Authors

Tao Liu^#¹, Ronghua Zuo^#², Jia Song^#¹, Jia Wang³, Zhijian Zhu¹, Lifang Sun¹, Shasha Wang¹, Baoyin Li¹, Yesheng Pan¹, Bing Wang¹

Affiliations

¹ Department of Cardiology, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai, 201500, People's Republic of China.
² Department of Anesthesiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People's Republic of China.
³ Department of Nephrology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, People's Republic of China.

^# Contributed equally.

Abstract

Objective: The association between serum uric acid (sUA) and incident abdominal aortic calcification (AAC), and severe abdominal aortic calcification (SAAC) in the general population of the United States (US) is unclear. Therefore, this research aimed to investigate the association between sUA and the risk of AAC and SAAC.

Methods: Individuals from National Health and Nutrition Examination Survey (NHANES) database were analyzed cross-sectionally between 2013 and 2014. The restricted cubic spline (RCS), multivariable logistic regression model and subgroup analysis were utilized to evaluate the correlation between sUA and incident AAC, and SAAC. In addition, generalized additive models with smooth functions were employed to survey the relationship between sUA and the degree of AAC.

Results: This study included 3016 individuals from the NHANES database. According to the RCS plot, sUA levels were associated with the risk of AAC/SAAC in a U-shaped pattern in the US population. The degree of calcification decreased at first and then increased with the increase in the sUA level.

Conclusion: Close monitoring and adequate control of sUA levels in the US general population may reduce the risk of AAC and SAAC.

Keywords: China; United States; abdominal aortic calcification; cross-sectional study; serum uric acid.

Grants and funding

This work was supported by the Shanghai Jinshan District Health Commission Project Fund (grant number: JSKJ-KTQN-2022-11), Shanghai University of Medical & Health Sciences Research Fund Project (grant number: SSF-23-25-002), and the Shanghai Jinshan District Medical and Health Science and Technology Innovation Fund Project (grant number: 2022-WS-61).