Chromatographic separation performance of silica microspheres surface-modified with triazine-containing imine-linked covalent organic frameworks

Haoyu Long; Yanhao Jiang; Yanjuan Liu; Yuefei Zhang; Wei Chen; Sheng Tang

doi:10.1016/j.talanta.2023.124589

Chromatographic separation performance of silica microspheres surface-modified with triazine-containing imine-linked covalent organic frameworks

Talanta. 2023 Aug 1:260:124589. doi: 10.1016/j.talanta.2023.124589. Epub 2023 Apr 28.

Authors

Haoyu Long¹, Yanhao Jiang¹, Yanjuan Liu², Yuefei Zhang¹, Wei Chen¹, Sheng Tang³

Affiliations

¹ School of Chemistry and Environmental Engineering, Key Laboratory of Green Chemical Process of Ministry of Education, Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Wuhan Institute of Technology, Wuhan, 430205, China.
² School of Pharmacy, Linyi University, Shuangling Road, Linyi, 276000, Shandong, China.
³ School of Chemistry and Environmental Engineering, Key Laboratory of Green Chemical Process of Ministry of Education, Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Wuhan Institute of Technology, Wuhan, 430205, China. Electronic address: stang@wit.edu.cn.

PMID: 37126925
DOI: 10.1016/j.talanta.2023.124589

Abstract

In this work, 2,4,6-tris(4-aminophenyl)-1,3,5-triazine (TAPT) and 1,3,5-tris(4-formylphenyl)benzene (TFPB) were used as monomers to construct a triazine-containing imine-linked covalent organic framework (COF), which was then bonded onto the surface of aldehydized silica (SiO₂-CHO), and finally a COF@silica composite material (TAPT-TFPB COF@SiO₂) was successfully prepared. The chromatographic separation performance of SiO₂-CHO, TAPT-TFPB COF@SiO₂ and TAPT-TFPB COF@SiO₂/SiO₂-CHO (80/20, mass ratio) was evaluated and compared. It was found that separation efficiency was obviously enhanced by adding an appropriate amount of SiO₂-CHO into TAPT-TFPB COF@SiO₂. The obtained TAPT-TFPB COF@SiO₂/SiO₂-CHO showed more favorable separation ability than SiO₂-CHO and TAPT-TFPB COF@SiO₂. Various aromatic compounds including alkylbenzenes, polycyclic aromatic hydrocarbons, environmental endocrine disruptors, foodborne stimulants and phenyl ketones were effectively separated on the TAPT-TFPB COF@SiO₂/SiO₂-CHO column in reversed phase chromatography mode. The silica microspheres surface-modified with triazine-containing imine-linked COFs proved to be a new type of promising chromatographic packing materials.

Keywords: Chromatographic separation; Covalent organic frameworks; Reversed phase chromatography; Silica gel; Stationary phase.