Heterologous mRNA vaccine boosters induce a stronger and longer-lasting antibody response against Omicron XBB variant

Matthew Zirui Tay; Yun Shan Goh; Siew-Wai Fong; Zi Wei Chang; Angeline Rouers; Nathan Wong; Anthony Torres-Ruesta; Yuling Huang; Sooriya Kannan Selvam; Pei Xiang Hor; Chiew Yee Loh; Bei Wang; Siti Nazihah Mohd Salleh; Eve Zi Xian Ngoh; Raphael Tze Chuen Lee; Vanessa Neo; Isaac Kai Jie Kam; Xuan Ying Poh; Suma Rao; Po Ying Chia; Sean W X Ong; Tau Hong Lee; Clarissa Lim; Jefanie Teo; NCID Study Group; PRIBIVAC Cohort Study Group; Sebastian Maurer-Stroh; Cheng-I Wang; Yee-Sin Leo; Raymond Tzer Pin Lin; David C Lye; Barnaby Edward Young; Lisa F P Ng; Laurent Renia

doi:10.1016/j.lanwpc.2023.100732

Heterologous mRNA vaccine boosters induce a stronger and longer-lasting antibody response against Omicron XBB variant

Lancet Reg Health West Pac. 2023 Apr:33:100732. doi: 10.1016/j.lanwpc.2023.100732. Epub 2023 Mar 7.

Authors

Matthew Zirui Tay¹, Yun Shan Goh¹, Siew-Wai Fong¹, Zi Wei Chang¹, Angeline Rouers¹, Nathan Wong¹, Anthony Torres-Ruesta¹, Yuling Huang¹, Sooriya Kannan Selvam¹, Pei Xiang Hor¹, Chiew Yee Loh¹, Bei Wang², Siti Nazihah Mohd Salleh², Eve Zi Xian Ngoh², Raphael Tze Chuen Lee^{3

4}, Vanessa Neo¹, Isaac Kai Jie Kam¹, Xuan Ying Poh⁵, Suma Rao^{5

6}, Po Ying Chia^{5

6

7}, Sean W X Ong^{5

6}, Tau Hong Lee^{5

6}, Clarissa Lim⁵, Jefanie Teo⁵; NCID Study Group; PRIBIVAC Cohort Study Group; Sebastian Maurer-Stroh^{1

3

4

8

9

10}, Cheng-I Wang², Yee-Sin Leo^{5

6

7

11

12}, Raymond Tzer Pin Lin^{5

8

13}, David C Lye^{5

6

7

12}, Barnaby Edward Young^{5

6

7}, Lisa F P Ng^{1

14

15}, Laurent Renia^{1

7

16}

Affiliations

¹ ASTAR Infectious Diseases Labs (A∗STAR ID Labs), Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
² Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
³ Bioinformatics Institute (BII), Agency of Science, Technology and Research (ASTAR), Singapore, Singapore.
⁴ GISAID Global Data Science Initiative (GISAID), Munich, Germany.
⁵ National Centre for Infectious Diseases, Singapore, Singapore.
⁶ Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.
⁷ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
⁸ National Public Health Laboratory, Singapore, Singapore.
⁹ Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
¹⁰ Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
¹¹ Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
¹² Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
¹³ Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
¹⁴ National Institute of Health Research, Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK.
¹⁵ Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
¹⁶ School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

No abstract available