A review on the role of LINC00511 in cancer

Soudeh Ghafouri-Fard; Arash Safarzadeh; Bashdar Mahmud Hussen; Mohammad Taheri; Seyed Abdulmajid Ayatollahi

doi:10.3389/fgene.2023.1116445

A review on the role of LINC00511 in cancer

Front Genet. 2023 Apr 14:14:1116445. doi: 10.3389/fgene.2023.1116445. eCollection 2023.

Authors

Soudeh Ghafouri-Fard¹, Arash Safarzadeh², Bashdar Mahmud Hussen³, Mohammad Taheri^{4

5}, Seyed Abdulmajid Ayatollahi⁶

Affiliations

¹ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
⁴ Institute of Human Genetics, Jena University Hospital, Jena, Germany.
⁵ Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁶ Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Long Intergenic Non-Protein Coding RNA 511 (LINC00511) is an RNA gene being mostly associated with lung cancer. Further assessments have shown dysregulation of this lncRNA in a variety of cancers. LINC00511 has interactions with hsa-miR-29b-3p, hsa-miR-765, hsa-mir-150, miR-1231, TFAP2A-AS2, hsa-miR-185-3p, hsa-miR-29b-1-5p, hsa-miR-29c-3p, RAD51-AS1 and EZH2. A number of transcription factors have been identified that regulate expression of LINC00511. The current narrative review summarizes the role of LINC00511 in different cancers with an especial focus on its prognostic impact in human cancers.

Keywords: LINC00511; biomarker; cancer; diagnostic; expression.

Publication types

Review

Grants and funding

This study was Financially supported by Shahid Beheshti University of Medical Sciences.