Ferroptosis in diabetic nephropathy: Mechanisms and therapeutic implications

Misganaw Asmamaw Mengstie; Mohammed Abdu Seid; Natnael Atnafu Gebeyehu; Getachew Asmare Adella; Gizchew Ambaw Kassie; Wubet Alebachew Bayih; Molalegn Mesele Gesese; Denekew Tenaw Anley; Sefineh Fenta Feleke; Melkamu Aderajew Zemene; Anteneh Mengist Dessie; Yenealem Solomon; Berihun Bantie; Tadesse Asmamaw Dejenie; Assefa Agegnehu Teshome; Endeshaw Chekol Abebe

doi:10.1016/j.metop.2023.100243

Ferroptosis in diabetic nephropathy: Mechanisms and therapeutic implications

Metabol Open. 2023 Apr 11:18:100243. doi: 10.1016/j.metop.2023.100243. eCollection 2023 Jun.

Authors

Misganaw Asmamaw Mengstie¹, Mohammed Abdu Seid², Natnael Atnafu Gebeyehu³, Getachew Asmare Adella⁴, Gizchew Ambaw Kassie⁵, Wubet Alebachew Bayih⁶, Molalegn Mesele Gesese³, Denekew Tenaw Anley⁷, Sefineh Fenta Feleke⁸, Melkamu Aderajew Zemene⁷, Anteneh Mengist Dessie⁷, Yenealem Solomon⁹, Berihun Bantie¹⁰, Tadesse Asmamaw Dejenie¹¹, Assefa Agegnehu Teshome¹², Endeshaw Chekol Abebe¹

Affiliations

¹ Department of Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
² Department of Physiology, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
³ Department of Midwifery, College of Medicine and Health Science, Wolaita Sodo University, Sodo, Ethiopia.
⁴ Department of Reproductive Health and Nutrition, School of Public Health, Woliata Sodo University, Sodo, Ethiopia.
⁵ Department of Epidemiology and Biostatistics, School of Public Health, Woliata Sodo University, Sodo, Ethiopia.
⁶ Department of Epidemiology and preventive Medicine, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia.
⁷ Department of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
⁸ Department of Public Health, College of Health Sciences, Woldia University, Woldia, Ethiopia.
⁹ Department of Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
¹⁰ Department of Comprehensive Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
¹¹ Department of Medical Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
¹² Department of Anatomy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.

Abstract

Diabetic Nephropathy (DN), the most common complication in diabetes mellitus, has been affecting the lives of people diabetic for a long time. Numerous studies have demonstrated the unbreakable connection between ferroptosis and kidney cell damage. Ferroptosis is a type of iron-dependent, non-apoptotic, regulated cell death, characterized by the buildup of intracellular lipid peroxides to lethal levels. Although the role of programmed cell deaths like apoptosis, autophagy, and necroptosis in the pathogenesis of DN has been demonstrated, the implication of ferroptosis in DN was least interrogated. Hence, the main aim of this review was to discuss the current understanding of ferroptosis focusing on its potential mechanisms, its involvement in DN, and emerging therapeutic opportunities.

Keywords: Diabetic nephropathy; Ferroptosis; Mechanism; Review; Therapeutic implication.

Publication types

Review