Autophagy in graves' ophthalmopathy

Yu-Qing Chen; Lian-Di Gao; Yi-Lin Liu; Ya Shen; Jia-Le Diao; Wei-Hua Yang; Rui-Li Wei

doi:10.3389/fcell.2023.1158279

Autophagy in graves' ophthalmopathy

Front Cell Dev Biol. 2023 Apr 14:11:1158279. doi: 10.3389/fcell.2023.1158279. eCollection 2023.

Authors

Yu-Qing Chen¹, Lian-Di Gao², Yi-Lin Liu², Ya Shen¹, Jia-Le Diao¹, Wei-Hua Yang³, Rui-Li Wei¹

Affiliations

¹ Department of Ophthalmology, Changzheng Hospital of Naval Medicine University, Shanghai, China.
² Department of Nursing, Changzheng Hospital of Naval Medicine University, Shanghai, China.
³ Shenzhen Eye Hospital, Jinan University, Shenzhen, China.

Abstract

Graves' ophthalmopathy (GO) is an inflammatory autoimmune disease that affects the eyes. It can significantly alter the quality of life in patients because of its distinctive pathological appearance and the effect on vision. To date, the exact pathological mechanism of GO has not been explicitly discovered. However, several studies have associated autophagy with this disease. Autophagy is a catabolic process that helps maintain homeostasis in all organisms by protecting the cells and tissues from various endogenous and exogenous stress factors. Based on our results, patients affected with GO have comparatively elevated levels of autophagy, which critically affects the pathological mechanism of the GO. In this review, we have summarized the autophagy mechanism in the pathogenesis of GO.

Keywords: adipogenesis; autophagy; glycosaminoglycan; graves’ ophthalmopathy; inflammation.

Publication types

Review

Grants and funding

This study was funded by the grants from the National Natural Science Foundation of China (Grant No. 81770959, Grant No. 81570885) and Major Clinical Research Project of Shanghai Shenkang Hospital Development Center (Grant No. SHDC2020CR1043B).