Protective Effects of a Polyphenolic Phytochemical Quercetin against Oxidative Dysfunctions in Rats

Ahmed I Foudah; Mohammad A Salkini; Hasan Soliman Yusufoglu; Huda Mohammed Alkreathy; Rahmat Ali Khan

doi:10.1155/2023/7858718

Protective Effects of a Polyphenolic Phytochemical Quercetin against Oxidative Dysfunctions in Rats

Evid Based Complement Alternat Med. 2023 Apr 20:2023:7858718. doi: 10.1155/2023/7858718. eCollection 2023.

Authors

Ahmed I Foudah¹, Mohammad A Salkini¹, Hasan Soliman Yusufoglu², Huda Mohammed Alkreathy³, Rahmat Ali Khan⁴

Affiliations

¹ Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
² Department of Pharmacognosy & Pharmaceutical Chemistry, College of Dentistry & Pharmacy, Buraydah Private Colleges, Buraydah 51418, Saudi Arabia.
³ Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
⁴ Department of Biotechnology, University of Science and Technology Bannu, Bannu, KPK, Pakistan.

Abstract

Background: Quercetin hastraditionally been used in various oxidative and urinary tract dysfunctions. Thecurrent project is consequently set to evaluate the defensive efficacy ofQuercetin against potassium bromate (KBrO3) induced testiculartissue oxidative dysfunctions through biochemical, hormonal, and genotoxicmarkers.

Methods: To observe theprotective efficacy of Quercetin against urinogenital oxidative dysfunction inrats, thirty six albino male rats were divided into six groups. Protectiveefficacies of Quercetin were checked on reproductive hormonal levels,antioxidant enzyme activities, lipids peroxidation (LP), and DNA damages.

Results: Potassium bromate exposure in experimentalanimals caused a reduction in the activities of antioxidant enzymes and disturbedhormonal secretions while enhancing the peroxidation of lipids andfragmentations of DNA. Cotreatment of Quercetin considerably (P<0.01)reversed these abnormalities with admiration to levels of hormones, antioxidantenzymes activities, and peroxidations of lipids secure to those seen inuntreated rats. (P < 0.01).

Conclusion: The findings of the current project revealedthat various doses of Quercetin are able to keep the testicular organ fromabnormal free radical dysfunctions. These improvements might be due to theantioxidant ability of polyphenolic bioactive constituent, i.e., Quercetin.