Advances in nanomaterial-based targeted drug delivery systems

Xiaoxiao Cheng; Qirong Xie; Yang Sun

doi:10.3389/fbioe.2023.1177151

Advances in nanomaterial-based targeted drug delivery systems

Front Bioeng Biotechnol. 2023 Apr 13:11:1177151. doi: 10.3389/fbioe.2023.1177151. eCollection 2023.

Authors

Xiaoxiao Cheng¹, Qirong Xie¹, Yang Sun¹

Affiliation

¹ Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, Chongqing, China.

Abstract

Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and biological properties. By combining therapeutic drugs with nanoparticles using rational targeting pathways, nano-targeted delivery systems were created to overcome the main drawbacks of conventional drug treatment, including insufficient stability and solubility, lack of transmembrane transport, short circulation time, and undesirable toxic effects. Herein, we reviewed the recent developments in different targeting design strategies and therapeutic approaches employing various nanomaterial-based systems. We also discussed the challenges and perspectives of smart systems in precisely targeting different intravascular and extravascular diseases.

Keywords: EPR; blood brain barrier; nano-drug delivery system; nanomaterials; surface modification; targeted delivery.

Publication types

Review

Grants and funding

This study was financially supported by the Innovation Leaders Program of Chongqing Talents (Grant No. CQYC20210303225), Senior Medical Talents Program of Chongqing for Young and Middle-aged (2020-219), Program for Youth Innovation in Future Medicine, Chongqing Medical University (2022-26).