Clinical results of neurorestorative cell therapies and therapeutic indications according to cellular bio-proprieties

Hongyun Huang; Paul R Sanberg; Gustavo A Moviglia; Alok Sharma; Lin Chen; Di Chen

doi:10.1016/j.reth.2023.03.004

Clinical results of neurorestorative cell therapies and therapeutic indications according to cellular bio-proprieties

Regen Ther. 2023 Apr 13:23:52-59. doi: 10.1016/j.reth.2023.03.004. eCollection 2023 Jun.

Authors

Hongyun Huang¹, Paul R Sanberg², Gustavo A Moviglia³, Alok Sharma⁴, Lin Chen⁵, Di Chen¹

Affiliations

¹ Beijing Hongtianji Neuroscience Academy, Beijing 100143, China.
² Center of Excellence for Aging & Brain Repair, Department of Neurosurgery & Brain Repair, Morsani College of Medicine, University of South Florida, Tampa 33612, Florida, USA.
³ Wake Forest Institute for Regenerative Medicine, Winston Salem, USA.
⁴ Department of Neurosurgery, LTM Medical College, LTMG Hospital, Mumbai, India.
⁵ Department of Neurosurgery, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100700, China.

Abstract

Cell therapies have been explored to treat patients with nervous diseases for over 20 years. Even though most kinds of cell therapies demonstrated neurorestorative effects in non-randomized clinical trials; the effects of the majority type cells could not be confirmed by randomized controlled trials. In this review, clinical therapeutic results of neurorestorative cell therapies according to cellular bio-proprieties or cellular functions were introduced. Currently it was demonstrated from analysis of this review that some indications of cell therapies were not appropriate, they might be reasons why their neurorestorative effects could not be proved by multicenter, randomized, double blind, placebo-controlled clinical trials. Theoretically if one kind of cell therapy has neurorestorative effects according to its cellular bio-proprieties, it should have appropriate indications. The cell therapies with special bio-properties is promising if the indication selections are appropriate, such as olfactory ensheathing cells for chronic ischemic stroke, and their neurorestorative effects can be confirmed by higher level clinical trials of evidence-based medicine.

Keywords: Cell therapy; Clinical trials; Evidence-based medicine; Nervous diseases; Neurorestoration.

Publication types

Review