Chitinase 3-like 1 induces cancer cell migration in solitary fibrous tumors

Biochem Biophys Res Commun. 2023 Jun 30:663:142-146. doi: 10.1016/j.bbrc.2023.04.057. Epub 2023 Apr 19.

Abstract

Solitary fibrous tumor (SFT) is a rare mesenchymal tumor that is diagnosed through the detection of the NAB2-STAT6 fusion gene. SFT rarely progresses to malignant tumors; however, metastasis is exhibited in approximately 20% of patients with SFT. In this study, we found that chitinase 3-like 1 (CHI3L1), which induces cancer cell migration, was upregulated in NIH-3T3 cells that were transfected with the NAB2-STAT6 fusion gene. Moreover, the expression levels of the migration markers MMP2 and MMP9 were increased and the p-Akt level was also upregulated. In addition, it was observed that when CHI3L1 siRNA was transfected into NAB2-STAT6-transfected cells, cell migration and proliferation were reduced. Therefore, this study demonstrated that CHI3L1 activates Akt signaling to induce cell migration.

Keywords: CHI3L1; Cell migration; NAB2-STAT6; Solitary fibrous tumor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers, Tumor / genetics
  • Cell Movement
  • Humans
  • Mice
  • Proto-Oncogene Proteins c-akt* / metabolism
  • STAT6 Transcription Factor / metabolism
  • Solitary Fibrous Tumors* / genetics

Substances

  • Proto-Oncogene Proteins c-akt
  • STAT6 Transcription Factor
  • Biomarkers, Tumor