Influence of design parameters and capsulorhexis on intraocular lens stabilities: A 3D finite element analysis

Kehao Wang; Yunxin Xia; Xiaofei Wang; Yutian Pu; Yune Zhao; Pingjun Chang; Barbara K Pierscionek; Yubo Fan

doi:10.1016/j.compbiomed.2023.106972

Influence of design parameters and capsulorhexis on intraocular lens stabilities: A 3D finite element analysis

Comput Biol Med. 2023 Jun:160:106972. doi: 10.1016/j.compbiomed.2023.106972. Epub 2023 Apr 26.

Authors

Kehao Wang¹, Yunxin Xia², Xiaofei Wang³, Yutian Pu², Yune Zhao⁴, Pingjun Chang⁴, Barbara K Pierscionek⁵, Yubo Fan⁶

Affiliations

¹ Key Laboratory for Biomechanics and Mechanobiology of Ministry for Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China; School of Engineering Medicine, Beihang University, Beijing, China.
² Key Laboratory for Biomechanics and Mechanobiology of Ministry for Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China; School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
³ Key Laboratory for Biomechanics and Mechanobiology of Ministry for Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China; School of Biological Science and Medical Engineering, Beihang University, Beijing, China. Electronic address: xiaofei.wang@buaa.edu.cn.
⁴ Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.
⁵ Faculty of Health, Education, Medicine and Social Care, Medical Technology Research Centre, Anglia Ruskin University, Bishops Hall Lane, Chelmsford, United Kingdom.
⁶ Key Laboratory for Biomechanics and Mechanobiology of Ministry for Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China; School of Engineering Medicine, Beihang University, Beijing, China; School of Biological Science and Medical Engineering, Beihang University, Beijing, China. Electronic address: yubofan@buaa.edu.cn.

PMID: 37120989
DOI: 10.1016/j.compbiomed.2023.106972

Abstract

Background: Current treatment of cataract widely used in clinics is by removal of the opacified content from the lens capsule which is followed by insertion of an artificial intraocular lens (IOL). The IOL needs to remain stabilized in the capsular bag for the eye to achieve desired optical quality. The present study aims to investigate how different design parameters of the IOL can influence the axial and rotational stabilities of IOLs using Finite Element Analysis.

Methods: Eight designs of IOL with variations in types of optics surface, types of haptics and haptic angulation were constructed using parameters obtained from an online IOL databank (IOLs.eu). Each IOL was subjected to compressional simulations both by two clamps and by a collapsed natural lens capsule with an anterior rhexis. Comparisons were made between the two scenarios on axial displacement, rotation, and distribution of stresses.

Results: The clamps compression method set out by ISO does not always produce the same outcome as the in-the-bag analysis. The open-loop IOLs show better axial stability while the closed-loop IOLs show better rotational stability when compressed by two clamps. Simulations of IOL in the capsular bag only demonstrate better rotational stability for closed-loop designs.

Conclusions: The rotational stability of an IOL is largely dependent on its haptic design whilst the axial stability is affected by the appearance of the rhexis to the anterior capsule which has a major influence on designs with a haptic angulation.

Keywords: Axial stability; Capsulorhexis; Cataract; Finite element analysis; Intraocular lens.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Capsulorhexis* / methods
Finite Element Analysis
Humans
Lens Implantation, Intraocular / methods
Lenses, Intraocular*
Prosthesis Design